Mitochondrial DNA Heteroplasmy in Human Health and Disease

Mitochondrial individual of inheritedmitochondrial polymorphisms heteroplasmy DNA exists andgenomes somaticas a dynamically mutations with repetitive determined in varying patterns coratios -expression of within tissuespecificity. Mechanistically, carcinogenic cellular processes include profoundalterations of normative mitochondrial function, notably dependence onaerobic and anaerobic glycolysis, and aberrant production and release oflactate,according to a classic theory.Within the translational context of humanhealth and disease, the present review discusses the necessity of establishingcritical foci designed to probe multiple biological roles of mitochondrial

heteroplasmy in cancer biology.